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Hypothyroidism and Depression – Is There a Connection?

​Is there a connection between hypothyroidism and depression?

Will taking thyroid medication reduce or even eliminate depression symptoms?

Do you still have depression even though you are on thyroid medication?

In this article, I will discuss the connection between hypothyroidism and depression, how thyroid medications can often help both conditions, and other causes of depression that you should consider…

​The ​Connection Between Hypothyroidism and Depression

​It is a​ well known fact​ in medicine that hypothyroidism is ​often associated with ​symptoms of depression. You will commonly find it listed as a symptom of hypothyroidism.  Click here for an example.

Doctors are even taught to check thyroid lab tests in any patient that presents with new symptoms of depression.

But how exactly are they connected?  We aren’t completely sure.

​However, we do know these connections:

  • ​Hypothyroidism and depression share similar symptoms.
  • Depression symptoms resolve in some people that are treated for hypothyroidism.
  • Thyroid hormone increases serotonin levels in the brain.
  • checkThyroid Releasing Hormone (TRH) is sensitive to serotonin.  Low serotonin levels may stimulate TRH production, while high serotonin levels may lead to lower TRH production.

​​Basically, depression symptoms can sometimes (but not always) be due to hypothyroidism.  If you ​treat the hypothyroidism, the depression symptoms will reduce or even resolve.

Let’s talk about depression a bit more…

​What Is Depression​?

​So what is depression anyway?  Most of us have no problem explaining the common symptoms that we call depression.

​When several people share a similar group of symptoms, ​medical organizations ​like to give it a name. This is to make things more simple, but​ it also makes it easier to bill insurance.

​The Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-5) lists the following criteria required to diagnose depression:

  • Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure.

    Note: Do not include symptoms that are clearly attributable to another medical condition.

    1. Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad, empty, hopeless) or observation made by others (e.g., appears tearful). (Note: In children and adolescents, can be irritable mood.)
    2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation.)
    3. Significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. (Note: In children, consider failure to make expected weight gain.)
    4. Insomnia or hypersomnia nearly every day.
    5. Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down).
    6. Fatigue or loss of energy nearly every day.
    7. Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick).
    8. Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others).
    9. Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.

​What ​this fails to take into account is what condition or conditions caused the symptoms in the first place!

If you are fatigued, moody, and are gaining weight since you hit menopause, should you be treated the same way as someone that just went through a divorce, or someone that is anemic​, or someone who has​ an autoimmune disease?

Of course not!

​Don’t think of depression as a ​diagnosis.  Instead, think of depression as a group of symptoms that may be caused by many different conditions.

In other words, it is a side effect of one or more other problems.  In order to properly treat the depression, the root cause must be identified and addressed.  This is the foundational principle of functional medicine.

​Possible Causes of Depression:

​1.  Hormone Imbalances

​​An imbalance in one or more hormones commonly results in symptoms of depression.

​An abnormality in these hormones should be ​one of the first things that you consider and test for when you are investigating the cause of your depression.

Examples of hormone imbalances includes menopause, low testosterone, and hypothyroidism.​

​2.  Nutrient Deficiencies

​Nutrient deficiencies ​commonly cause anemia and other conditions that result in depression symptoms.

These include B12, folic acid, and iron.

If you don’t test for them you will never know if you are deficient or not!

​3.  Gut Dysfunction

​Gut dysfunction can lead to the nutrient deficiencies listed above, it can result in a decrease in neurotransmitter production such as serotonin, and it is a primary reason why​ autoimmune disorders develop.

Most diseases in the body ​is worsened or even starts with gut dysfunction.  In fact, when I have a difficult patient and I’m not sure what to do, I start with working on their gut.

​Gut issues include lack of stomach acid, SIBO or SIFO, and dysbiosis.

​4.  Inflammatory States

​Inflammation causes a decrease in energy production in the mitochondria of the cells.  This results in fatigue, insomnia, chronic pain, and other symptoms of depression.

Examples include insulin resistance, leptin resistance, autoimmunity, and acute and chronic infections.

Most of these can be detected with proper lab testing.

​5.  Insomnia

​Lack of sleep causes mood swings, fatigue, poor concentration, and other symptoms of depression.

​6.  Alcohol Use

​Alcohol abuse ​has been shown to be associated with depression in several studies.

​7.  Stress

​Stress (particularly chronic stress) has been closely associated with depression.

​8.  Spiritual/Religious Issues

​Studies have shown that pursuing religion and spiritual beliefs can help reduce depression symptoms.  ​Guilt and conviction of not following or pursuing your personal religious beliefs could be a major source of stress that will need to be addressed.

​IT IS IMPORTANT TO REALIZE THAT it is possible and even probable that your depression is multifactorial – meaning ​it could be ​caused by several of the reasons listed above.

Treating only one of the causes may not significantly reduce your symptoms.  It will be necessary to address ALL of the causes to get the most benefit.

​Hashimoto’s and Depression

​Since up to 90% of hypothyroidism is caused by Hashimoto’s Thyroiditis, it deserves discussion as well.

As you know, Hashimoto’s is an autoimmune disorder that if left un​treated will ​slowly and gradually destroy the thyroid gland, resulting in hypothyroidism.

​One of the things that makes Hashimoto’s even more difficult than hypothyroidism is the fact that the TSH will often be in the “normal” range even though the patient may be having significant​ symptoms such as depression, constipation, fatigue, etc.

That is ​important because if the TSH is normal, very few doctors will give those patients thyroid medication, even if they have are having symptoms.  As we will discuss later in this article, thyroid medication can often greatly reduce depression symptoms.

Studies show that patients with Hashimoto’s are at increased risk of developing both depression and anxiety, even when their TSH is normal.

In fact, it appears that thyroid antibodies themselves can ​actually cause depression symptoms.

​It is therefore ​crucial to get a complete thyroid panel, including free T4, free T3, TPO antibody, and thyroglobulin antibody levels.  That will give you a​n indication of whether you are deficient in thyroid hormone​ at the cellular level and if you have ​autoimmune thyroid disease.

If someone is having depression symptoms and they have a normal TSH but a low free T3, starting a trial of thyroid hormone medication may be warranted.

They may also benefit from other Hashimoto’s therapies that help reduce antibody levels.  These can include selenium and zinc supplementation, vitamin D supplementation, LDN therapy, and others.  I discuss many of these in other blog articles on my website.

Click here to read more about ​treatments for Hashimoto’s.

​Treatment of Depression with Thyroid Medication

​Studies have shown that thyroid medication can be very effective in treating depression and depression symptoms.

It can ​reduce depression symptoms when added to an SSRI (the standard conventional treatment for depression) as shown in this study.

​Giving T3 medication has also been shown to be effective at treating depression even when patients are resistant to standard SSRI treatment.

There are also studies that show using T3 by itself is effective at reducing depression symptoms.

Of note, T3 has also been shown to be effective in treating mood disorders such as bipolar disorder, even when patients have failed multiple mood stabilizing medications.

​So why does thyroid hormone (particularly T3) help with depression?

​These studies show that there is probably a connection between mood and thyroid function.

There may even be a subset of depressed patients that actually have ​hypothyroidism that has not been identified.

There is also the possibility that some patients may have a genetic defect in one of the deiodinase enzymes that converts T4 to T3.  This may result in a decreased level of T3 circulating in the brain.

I believe that it is good medicine to have a complete thyroid panel drawn on all patients that have symptoms of depression.

If you have failed multiple depression therapies and medications, it ​would even be reasonable to try a trial of thyroid medication, especially if your free T3 level is not optimal.

The best thyroid medication to use is Cytomel or liothyronine, which is a T3 only medication.  This is the strongest thyroid medication available and does not require conversion by a deiodinase to work.

This can be done safely if th​ese guidelines are followed, which is further explained in this article:

  • ​Check TSH, free T3, and free T4 prior to starting treatment
  • Start with liothyronine 25mcg daily and titrate slowly over weeks depending on tolerance to the medication.  Most patients will need 50-150mcg daily
  • ​Recheck thyroid labs at least every 3-6 months, or more often if needed
  • checkThe goal for TSH should be in the lower limits of the reference range (or even lower at times depending on the free T3 level)
  • checkThe goal for free T3 should be in the upper limits of the reference range
  • checkIf you are menopausal, bone density should be monitored regularly

​T3 medications can sometimes cause ​side effects such as jitteriness, palpitations, excessive sweating, headache, and other symptoms.  Make sure you communicate any of these with your doctor if you are taking T3 medication.

​Some people simply cannot tolerate liothyronine due to side effects.  In those situations, a compounding pharmacy can make sustained-release T3 (SR-T3) which is typically much better tolerated.

​7 Steps to Consider if You Have Depression

​If you​ are suffering from depression, I would recommend that you follow the 7 steps below to ​help reduce or eliminate your symptoms:

​1.  Get a Complete Thyroid Panel

​Just checking a TSH level is woefully inadequate to truly evaluate your thyroid function.  Instead, I STRONGLY recommend that you ask your doctor to check all of the following tests:

​If either antibody test is >35, then a diagnosis if Hashimoto’s Thyroiditis can be made.

​If the free T3 level is < 3.5, that is an indication of hypothyroidism regardless of the TSH level, especially if you are having several symptoms of hypothyroidism.

​2.  Consider adding T3 medication to your current regimen

​Many people have issues with T4 to T3 conversion due to chronic inflammation and gut issues​.  Adding T3 to your other thyroid medication bypasses the need for the conversion step which will allow more active thyroid to reach the cells of the body, including the brain.

As little as 5-10mcg of liothyronine can be helpful.

​3.  ​Reduce your thyroid antibodies if you have Hashimoto’s

​Reducing thyroid antibodies will help in numerous ways.  This includes reducing systemic inflammation which improves thyroid conversion ​plus helps you feel better in general.  It also reduces depression symptoms directly.  Finally, it typically improves hypothyroidism which will help reduce symptoms.

​4.  ​Identify and treat and nutrient deficiencies

​These include vitamin B12, folate, and iron.  There are lab tests that test for these directly.  Treatment consists of supplements and improving gut health.

​5.  Get good sleep

​It is almost impossible to maintain good overall health if you are getting less than 7-8 hours of good sleep per night.

Here is a fascinating interview of Matthew Walker, a neuroscientist who is considered one of the premiere sleep experts in the world if you want to learn more (warning- there is ​cursing by the host in the interview).

Improving your sleep may actually be the single most potent tool that you can do to combat your depression.

​6.  Manage your stress

This is always an easy thing to say, but a hard thing to do.

Reducing your stress may need to include changing jobs, ending unhealthy relationships, and placing​ healthy boundaries in your life.

​I would also recommend adding meditation and/or yoga to your daily routine.

​7.  Address any spiritual needs

​Depending on your particular situation, this can include speaking to your pastor, priest, or spiritual advisor, and re-committing yourself to pursue a deeper meaning in your life.

​Important Note:  You may still ​need the use of an anti-depressant (at least for awhile), but finding the root causes of your depression and dealing with them directly will greatly improve​ your success in reducing or eliminating your depression symptoms.

​Summary

​Many patients that have been diagnosed with depression also have thyroid issues, including hypothyroidism and Hashimoto’s.

In many cases, adding T3 thyroid medication can reduce depression symptoms, even when their TSH is normal.

If you have depression and hypothyroidism and are taking a T4 only thyroid medication, you may want to talk to your doctor about adding T3 or changing your thyroid medication to one that contains T3.

It is important to get a complete thyroid panel to accurately assess your T3 levels and to check for the presence of Hashimoto’s.

As with most conditions, finding the root causes of your depression will allow you to directly address the issues that apply to you.

​Now it’s your turn…

Do you have a thyroid issue?  Do you also have depression?

Have you tried taking T3 medication to treat your depression?

What has worked for you?  What hasn’t worked?

Leave your questions and comments below.

How to Use Liothyronine (T3) in Hypothyroidism

​Liothyronine (T3) is ​the most potent thyroid hormone that you can take.

It is rarely prescribed by most doctors, which is unfortunate, because it can significantly improve your hypothyroid symptoms and overall quality of life.

The symptom improvements can include ​improved energy, weight loss, and even a reduction in depression.

​Learn who could benefit from using liothyronine, how to use it safely, and lots more in this article…

More…

What is Liothyronine?

​In order to understand liothyronine, it is important that you ​understand the basic physiology of the thyroid. You can read more in depth about it by clicking here.

Liothyronine is T3.  T3 is one of the 2 main circulating thyroid hormones in your bloodstream.

T4 is the inactive thyroid hormone.  The vast majority of hormone made by the thyroid gland is T4.

T4 itself ​has no activity in the body.  In order for it to be​come an active hormone, it must be converted into T3​.  An iodine molecule is cleaved off of the T4 by an enzyme called a deiodinase, which ​results in the production of T3.

T4 can be looked at as the storage reservoir for thyroid hormone in ​your body.  When your body needs more active thyroid hormone, it can convert the T4 that is circulating in the blood into active T3.

​By understanding that T4 is the inactive form of thyroid and T3 is the active form, it then makes sense why ​oral T3 medication is much more potent than oral T4 medication.  In fact, it is about 3-4 times more potent.

Liothyronine vs. Levothyroxine

​If Liothyronine is so powerful, then why don’t more doctors prescribe it?

​Most doctors simply were not taught how to prescribe T3 medication and manage patients that are taking it.  They ​were also not taught which labs need to be monitored and how to interpret those test results.

I ​was personally NEVER taught about T3 medications in my many years of training.  I have had to learn about it myself through attending multiple medical conferences, reading tons of literature, and asking doctors with experience ​prescribing it how they use it.

It is simply assumed by most doctors that all patients have no issues with converting T4 to T3.  If that was the case, every patient could just take a T4 only medication such as Synthroid, levothyroxine, or Tyrosint and it would seamlessly be converted to T3 when the body needed it.

Wouldn’t that be easy?

However, most people with thyroid issues have a reduced ability to convert T4 to T3.  Instead, much of the T4 is converted into the anti-thyroid metabolite reverse T3 which results in a condition called reverse T3 dominance.  This is usually due to chronic inflammation in the body and/or a deficiency of nutrients such as iodine, selenium, or zinc.

​That is why you may be on a ​good dose of a T4 only medication which results in a normal ​TSH and T4 level, yet you still have symptoms of hypothyroidism.

In those situations, when used and monitored properly, liothyronine can be a safe and extremely effective medication to treat your hypothyroidism and improve your symptoms.

One study showed that replacing T4 with T3 resulted in weight loss and greater thyroid action on lipid metabolism, without an increase in side effects.

Who Should Use Liothyronine?

​Not everyone who takes thyroid medication necessarily needs to take liothyronine.

​Besides having hypothyroidism, if you are otherwise healthy, energetic, and feel great, your conversion of T4 to T3 is probably adequate and you may not need to change from your T4 only medication.

Now, for the other 99% of you (ha!), you may want to get a complete thyroid panel so that you can truly assess the T4 and T3 levels in your body:

​You should also consider getting a sex hormone binding globulin level (SHBG), which can also help give you an idea of the thyroid levels in your body (if you are on oral birth control pills or estrogen or if you smoke, this test will not be helpful).

​If your reverse T3 level is >15, your free T3 level is ​<3.5, and/​or your SHBG level is <20 in men or <60 in women (who aren’t taking oral estrogen), then your T3 level is inadequate and you ​may want to consider adding T3 in some form to your regimen.

Below is a general list of people who may need to add T3 to their thyroid medication regimen:

  • checkPatients with low serum levels of free T3 (<3.5)
  • checkPatients with high levels of reverse T3 (>15)
  • checkPatients with “normal” TSH and T4 levels but still remain symptomatic despite taking T4 only thyroid medication
  • checkPatients with chronic inflammatory conditions such as an autoimmune disease, insulin resistance, and leptin resistance
  • checkPatients that have persistent difficulty with weight loss
  • checkPatients with treatment resistant depression and treatment resistant bipolar disorder

​This is by no means an exhaustive list, but it includes the majority of patients that m​ay benefit from taking T3.

​What about Natural Dessicated Thyroid (NDT)?

​If you are currently taking a T4 only medication (Synthroid, levothyroxine, or Tyrosint), changing to an NDT medication such as Armour Thyroid, NP Thyroid, or Nature-throid may be the easiest ​thing to try to increase your T3 level.  In fact, that is usually the first thing I will do for patients.

NDT is about 80% T4 and 20% T3.  While that is certainly better than a ​medication with 100% T4, that may still be too much T4 which ​could result in a high level of reverse T3.

If​ you are taking an NDT medication and your reverse T3 levels are too high and your free T3 levels are too low, you may need to reduce your NDT dose (at least temporarily) and add a small dose of liothyronine in order to “flush out” the reverse T3 which will allow the T3 ​levels to rise to optimal levels.

Liothyronine for Weight Loss

​Liothyronine may cause weight loss but it should NOT be used as a weight loss medication.

​If used for weight loss in patients without thyroid dysfunction, it could cause some unpleasant and even dangerous side effects.

However, liothyronine may help with weight loss in patients with hypothyroidism.

T3 may cause more weight loss than T4 because of how it interacts with fat cells and other hormones in the body.

T3 directly increases mitochondrial energy production and increases thermogenesis and fat burning potential.

Liothyronine for Depression

​Liothyronine can also reduce symptoms of depression.

Low thyroid levels (hypothyroidism) are known to commonly result in symptoms of depression.

What you may not know is that adding liothyronine to an antidepressant ​can improve mood and cognitive function even when the thyroid function is normal.

The exact mechanism is not fully understood, but it is believed that some patients with depression may have subclinical hypothyroidism that is not bad enough to be detected on standard lab tests but still causes typical symptoms of depression.

Therefore, by treating those patients with liothyronine, it may correct those subtle thyroid abnormalities in the brain which will help resolve the depression symptoms.

T3 has also be shown to increase the receptor sensitivity to serotonin and increase the synaptic concentrations of serotonin.

Since the most commonly used antidepressants are only successful in treating depression in about 50% of cases, the addition of liothyronine ​is a viable option to consider, especially in “treatment resistant” cases.

If you are on a T4 only thyroid medication and are still suffering from depression, adding liothyroinine to your T4 medication may significantly improve mood and neuro​psychological function.

​How to Raise T3 Levels

​The whole point of even ​discussing liothyronine is because we want to raise the ​active thyroid levels (T3) in the body to optimal levels.

​Taking T3 medication (liothyronine) will obviously accomplish that goal.  There are ​also some natural things that should be considered that will result in increased levels of T3.  Let’s discuss those ​as well as how to take ​liothyronine…

​1. Naturally Increase T4 to T3 Conversion

​The conversion of T4 to T3 is dependent on a few nutrients.

​It is common for people to be deficient in these nutrients because they may be lacking in their diet or they may have gut issues such as leaky gut that reduce the absorption of the nutrients.

Some of the most important nutrients include:

  • checkZinc – Zinc has been shown to improve conversion of T4 to T3, acts and a strong anti-inflammatory, and reduce oxidative stress.  Zinc deficiency is VERY common in the US. Standard zinc supplementation is also inadequate because it does not have zinc bound to picolinic acid (which is the most absorbable form of zinc).  Doses of 30-60mg per day are recommended.  It is important to take it with selenium.
  • checkSeleniumSelenium can improve thyroid conversion, act as an anti-inflammatory, and help balance the immune system.  It is also very helpful if you have an autoimmune thyroid issue such as Hashimoto’s.  Doses of 200-400mcg per day are recommended. Best if taken with zinc.

​2. Naturally Lower Reverse T3 Levels

​Another way that you can raise T3 levels and improve its function is to lower reverse T3 levels.

Remember, reverse T3 is the anti-thyroid metabolite that binds to thyroid receptors on the cells but blocks their function.

By reducing the amount of reverse T3, it will in effect improve T3 function.

So how do you do it?  Address the issue that is causing the reverse T3 level to be increased in the first place.

Easier said than done, but below is a list of common issues that result in elevated reverse T3 levels:

  • checkReduce Inflammation – Inflammation from any cause will increase reverse T3 levels and reduce thyroid function.  Checking ESR and CRP lab tests will indicate how much inflammation is present.  If those test are elevated, consider taking anti-inflammatory supplements such as tumeric, fish oil, and quercetin+bromelain.
  • checkFix Your Gut – ​Treating conditions such as leaky gut or SIBO are essential to improve your thyroid function.  Up to 20% of thyroid conversion occurs in the gut, plus absorption of nutrients that are vital to normal thyroid function may be impaired.  About 50% of thyroid patients have SIBO/SIFO and don’t even know it.  Read more about it here.
  • check​Lower Your Insulin Level – High insulin and sugar levels inhibit the ​T4 to T3 conversion process and ​contribute to weight gain.  If your fasting insulin is >5, you most likely have insulin resistance which much be addressed.  Supplements that help reduce insulin resistance include alpha-lipoic acid, berberine, and chromium.
  • checkLower Your Leptin Level – Leptin is another hormone that is usually involved with weight loss resistance.  It also reduces thyroid function by increasing inflammation in the body which impairs the T4 to T3 conversion process.  ​Read more about how to reduce it here.
  • checkStop Extreme Dieting – If you are eating less than 1500 calories per day just to maintain your weight, you are damaging your metabolism and lowering your T3.

​3. Short-acting Liothyronine (Cytomel)

​Cytomel is the brand name for liothyronine, but over the past few years generic versions have become available that are less expensive.  ​

Liothyronine is available in 3 strengths – 5mcg, 25mcg, and 50mcg.  I personally have never prescribed the 50mcg dose.

​Typically, the 5mcg dose is prescribed first, then it may be increased to 10mcg (2 tablets) depending on the patient response and labs.  If more is needed, usually 1/2 pill of 25mcg is given, then possibly a full 25mcg tablet.

– Liothyronine/levothyroxine in Combination

​This is by far the most common way that liothyronine is used.  Fortunately, medical providers are becoming more comfortable using it so its use is expanding.

Liothyronine is added to the patient’s current dose of T4 medication (levothyroxine).

Remember, liothyronine is 3-4 times more potent than levothyroxine, so you will need to be aware of any side effects and your labs will need to be monitored closely.

If your TSH is suppressed excessively, it may be necessary to reduce your dose of levothyroxine.

– Liothyronine only

​Most physicians will not be comfortable prescribing liothyronine by itself.

​This is because most medical committees recommend using a T4 thyroid medication as first-line treatment of thyroid issues.

However, many patients ​with weight loss resistance, leptin resistance, and other hormone imbalances may benefit from using T3 by itself.

T3 medication can be used temporarily to boost the body back into action or it can also be used long-term.

As long as it is used correctly and monitored closely there should not be any long-term consequences in using it.

If you are interested in using it, you must find a doctor with experience in prescribing it, and you must be willing to get regular lab tests and follow-ups with your doctor.

4. Sustained-Release (SR) T3

​Occasionally patients may be extremely sensitive to T3 medication.  In those situations, it may be necessary to have a compounding pharmacy ​make a sustained-release ​form of T3.

The sustained-release formulation will ​allow the T3 to be released ​gradually over a longer period of time which will reduce the side effects that the T3 may cause.

Liothyronine Side Effects

​Some patients tend to be very sensitive to T3 medication.  This usually causes them to feel jittery or anxious when they start the medication.

If you have a history of being sensitive to other medications, you need to let your doctor know before starting T3.  You can probably still take it, but you will need to go “low and slow” with it.

As a general rule, I have found that women tend to be more sensitive to T3 than men, although there are certainly exceptions with both.

The side effects of liothyronine seem to mirror those caused by hyperthyroidism.  These include:

  • checkJitteriness – usually dose-dependent and from taking too much
  • checkPalpitations – usually a sign that the dose is too high
  • checkNausea 
  • checkHair Loss – usually temporary and resolves in 3-6 months
  • checkHeadache – usually an indicator that the dose is too high
  • checkTremor – usually dose-dependent
  • checkSensitivity to Heat – and indicator that the dose is too high
  • checkAnxiety – an indicator that the dose is too high

​If you develop any of these symptoms you should notify your prescribing doctor and discuss treatment options.

Summary

​Liothyronine is a T3 only medication.

It is the most potent thyroid medication available.

When used correctly and closely monitored, liothyronine is extremely effective in treating hypothyroidism and reducing symptoms.  It typically causes some weight loss as well.

It can also be used to treat resistant depression.

​Now it’s your turn…

Have you ever taken liothyronine?  If so, what were the results?

Leave any questions or comments below.